Overcome Depression with Pyridoxine Vitamin B6

Overcome Depression with Pyridoxine Vitamin B6

High protein foods like meat, poultry, fish and eggs digest in the body and break down into tiny particles called amino acids. There are approximately twenty nutritional amino acids and nine of them are essential. That means that they are essential to good health and must come from the diet.

These amino acids all have different names and perform different functions in the body. In particular, the amino acids phenylalanine, tyrosine, and tryptophan convert to brain chemicals called neurotransmitters. These amino acids are the food ingredients that the body requires to build these neurotransmitters.

These neurotransmitters, serotonin and dopamine, diminish from stress, poor diet and aging and it results in depression.

Drug companies make antidepressants (SSRI’s) like Prozac, Zoloft and Paxil that make more of these neurotransmitters available. They do not replenish the neurotransmitters they merely make more of what is there available.

This can be counter productive. It would be best if they actually made more of the neurotransmitters because eventually they can exhaust the total supply, which leads to more depression.

To rebuild these neurotransmitters naturally, taking the amino acids as supplements can replenish them naturally without the side of effects of the above drugs. For more information on using these supplements, see the articles on Overcoming Depression Naturally with Tyrosine and Tryptophan.

Often the diet does provide all of the necessary amino acids however; vitamin B6 (pyridoxine), vitamin C and magnesium are required to complete the conversion to these depression-relieving neuro- transmitters. They are often in short supply and prevent the conversion. Therefore, vitamin B6 is frequently the necessary missing link needed to overcome depression.

An effective general use dose of pyridoxine, vitamin B6, is 50 to 100 milligrams for most regular daily needs. Pyridoxine is water-soluble and dissipates within about four hours. Therefore, take it twice a day.

For some people pyridoxine, vitamin B6, does not convert properly to its active form, pyridoxal-5-phosophate. This form is available to purchase and is more potent. The suggested dosage is 25 to 100 milligrams twice a day of pyridoxal-5-phosphate. To enhance its effect take it alone at one meal then with the other B vitamins at another daily meal.

It is also beneficial to take both pyridoxine and pyridoxal-5-phosphate at the same time with pyridoxine being eighty percent of the dose and pyridoxal-5-phosphate twenty percent of the dose.

Inasmuch as vitamin C and magnesium citrate work together with vitamin B6, take 500 milligrams of vitamin C and 500 milligrams of magnesium citrate with the pyridoxine or pyridoxal-5-phosphate.


Do not take pyridoxine or individual B Vitamins by themselves. There are eleven B complex vitamins and they work together (Synergistically). Taking only one vitamin like vitamin B6 could create a deficiency of vitamin B2 and vitamin B5. Always take a high quality B50 complex containing mostly 50 milligrams of the B vitamins when taking B vitamins.

Note: Most Vitamin B50 or B100 formulas do not contain 50 or 100 milligrams of each vitamin. There are lesser quantities of some vitamins such as folic acid.

The eleven B complex vitamins are; B1 (Thiamine), B2 (Riboflavin), B3 Niacinamide, B5 (Pantothenic Acid), B6 (Pyridoxine), Biotin, PABA, Folic Acid, B12 (Cobalamin), and Choline and Inositol. Ideally use a B50 complex. In general, vitamin B6 should not be taken in doses over 500 milligrams daily.

Note: The FDA regulates the amount of Folic Acid in vitamin preparations to .800 micrograms (less than one mg). Research shows that this dosage is not adequate. The consensus is that the requirement is at least five milligrams daily.

Nothing on this site is a replacement for professional medical advice. Always seek the advice of your physician or health care provider.